2019 Conference Prolactinoma

PROLACTINOMA
Shahin Nosratzehi

Agenda

• Epidemiology
• Diagnosis

• Clinical consequences of hyperprolactinemia
• Biochemical diagnosis
• Imaging

• Medical treatment
• Surgical treatment
• Prolactinoma and pregnancy

Epidemiology

• Prevalence: 50 per 100,000
• incidence 3-5 new cases/100,000/year.
• microadenomas are 4-5 fold more frequent than macroadenomas
• The ratio between macro- and microprolactinomas is approximately 1:8 in women, whereas it is inverted in men (macroadenomas in 80% of cases)
• predominance of PRL-secreting tumors is observed in women aged 25-44 years compared to men ( male to female ratio of 1:5 to 1:10) while this difference disappears after menopause.
• peak age of occurrence in women occurs at approximately 30 years, while most men are diagnosed after age 50.